| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
여성연구자 특별 심포지움 (일반구두발표(Post-Doc., 발표 20분) 및 대학원생 구두발표(발표 15분)만 신청 가능)* |
| 제목 |
Reactive Oxygen Species Scavenging Injectable Hydrogel with Cytoprotective Effect under Oxidative Stress for Tissue Regenerative |
| 초록 |
The overexpression of reactive oxygen species (ROS) contributes to the pathogenesis of numerous diseases, such as atherosclerosis, myocardial infarction, cancer, and chronic inflammation. In this study, we developed an injectable gelatin-hydroxyphenyl propionic (GH) hydrogels incorporating antioxidant gallic acid on the gelatin backbone (GGA) to locally scavenge the excessive ROS and suppress the oxidative stress injury. The hydrogels were rapidly formed within 10 sec via horseradish peroxidase-catalyzed cross-linking in the presence of hydrogen peroxide. The hydrogels effectively scavenged the hydroxyl radicals (76-91%) and DPPH radicals (35-59%) by varying the amount of incorporated GGA. Moreover, the hydrogels significantly preserved the cell viability under ROS microenvironment by reducing the intracellular ROS production. These results suggest that GH/GGA hydrogels can serve as promising injectable cell/drug delivery platforms for treatment of diseases with local oxidative stress. |
| 저자 |
풍, 박기동
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| 소속 |
아주대 |
| 키워드 |
Injectable hydrogel; Reactive Oxygen Species; Tissue regeneration
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| E-Mail |
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