| 초록 |
Total cost of health and long-term care in Japan is increasing year by year and will reach 10 trillion, because of progress of late aging society. Cause of increases of these costs is disruption of healthy life expectancy from average life expectancy mainly due to Alzheimer's disease, cardiac failure, osteoporosis, rheumatism, and metabolic syndromes. In recent research, it was revealed that inflammation induced these diseases as the common cause. Our research group focuses focused on apoptotic cell death which completes cell death without inflammation. We expected establishment of new therapeutic method by mimic the mechanism of apoptotic cell death. It is well known that apoptotic cells regulate pathological inflammation by exposing phosphatidylserine (PtdSer) on the outer leaflet of the plasma membrane. Especially, phosphoryl serine (PS) group which is a head group of PtdSer plays most important lore for inflammatory suppression. Therefore, we develop a novel synthesis method of apoptotic cell membrane-inspired polymers and demonstrate the anti-inflammatory effects using macrophages. |
