| 초록 |
A gold nanoparticle-based drug vector was designed for verteporfin delivery for photodynamic therapy (PDT). Verteporfin has been approved for PDT of abnormal blood vessels in the eye, including the wet form of macular degeneration. In this study, the vertepotfin vector was developed by designing multifunctional and biodegradable block copolymer-gold nanoparticle (AuNP) conjugates, which act as a water-soluble and biocompatible carrier that allows delivery of a hydrophobic photosensitizer to tumor site for PDT action. The FA-PEG-P(Asp-Hyd)-DHLA-modified AuNPs became so stable that their optical property did not change under very harsh conditions. Then, hydrophobic photosensitizers were conjugated to the stable vectors through pH-sensitive linkage. The particle size, size distribution, and morphology of FA-PEG-P(Asp-Hyd)-DHLA-modified AuNPs were investigated. |
