| 초록 |
The tissue engineering scaffold should be mechanically stable and capable of functioning biologically in the implant site. Recently, a variety of techniques have been developed for nano- or submicron fiber fabrication, including phase separation, electrospinning, and self-assembly. Among them, electrospinning provides a straightforward way to fabricate fibrous scaffolds with nano-sized diameter of fibers. In this study, nanofibrous scaffold was obtained by electrospinning of PHBV and proteins. The resulting fiber diameters were in the range of 400 ~ 1000 nm. The nanofiber surfaces were characterized by ATR-FTIR, ESCA, and AFM. It was found, from cell culture experiments, that the PHBV/gelatin nanofibrous scaffold accelerated the adhesion and proliferation of NIH 3T3 compared to the PHBV nanofibrous scaffold. Thus the PHBV/gelatin nanofibrous scaffold has a great potential to be used in the field of tissue engineering. |
