| 초록 |
The anti-solvent crystallization technique is widely used to crystallize various organic compounds such as explosives, polymers, and pharmaceuticals. In this study, a model drug compound, Ibuprofen(IBU) was recrystallized from two different solvents (acetone and Ethanol) and antisolvents (water and hydrogen peroxide). IBU was dissolved in organic solvents and the solutions were mixed with antisolvents leading to particle precipitation. The habit of the precipitated crystals was modified by changing the process conditions, such as the temperature, presence of ultrasonic waves, and concentration of solute. Properties of morphology, particle size, and thermal properties of the IBU crystals obtained from antisolvent experiments were compared. Also, an external additive was used to solve the agglomeration phenomenon, which is the chronic problem of crystallization. A significant reduction in particle size and completely disentangled the agglomeration were achieved. |
