| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Odorless glutathione microneedle patches for skin whitening |
| 초록 |
Glutathione is a natural anti-aging agent, preventing protein thiol oxidation from reactive oxygen species. In pharmaceutical industry, reduced glutathione (GSH) has been widely used for skin whitening due to tyrosinase inhibitory activity. However, its low skin permeability and foul odor limit use in topical applications. Herein we report a GSH-loaded dissolving microneedle (MN) patch, enabling enhanced permeation across skin and reducing the foul odor of GSH. Biopolymers as a carrier of GSH have been screened for odorless formulations and were used for MN fabrications. GSH-loaded MN (GSH-MN) array with good pattern fidelity showed enough mechanical properties to be inserted into the skin. GSH-MN patch with 550 ug of GSH in tips dissolves within 10 minutes following insertion into porcine skin and releases the drug (GSH) without getting oxidized. This new approach could improve the skin whitening and antioxidant property of GSH. |
| 저자 |
이예찬1, 김채린1, Sujeet Kumar2, 성금용1, 이혜선1, 양승윤1
|
| 소속 |
1부산대, 2Pusan National Univ. |
| 키워드 |
glutathione; skin whitening; transdermal drug delivery; microneedle.
|
| E-Mail |
|
