| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Hydroxyapatite coated PLGA microspheres for sustained release |
| 초록 |
PLGA microspheres are widely used for sustained release. However it is difficult to control of release, such as initial burst release. Therefore this study attempted to overcome these problems by hydroxyapatite coated PLGA microspheres. DP(donepezil) was encapsulated in PLGA microsphere by the O/W emulsion-solvent evaporation method. And the microspheres were soaked with CaCl2 solution, then added KH2PO4 solution to coat. As a result, the drug loading efficiency was 20 % and encapsulation efficiency was 78%. We confirmed the thickness of the coating was increased as the soaking time increased using SEM and optical microscope. The release of coated DP loaded microspheres was delayed slightly. These characteristics are expected to be used to control the size of the hydroxyapatite coated microsphere for sustained release. |
| 저자 |
강석희, 양태경, 허수진, 김경도, 조선행, 신병철
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| 소속 |
한국화학(연) |
| 키워드 |
PLGA microsphere; donepezil; sustained release; DDS; Drug delivery system
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| E-Mail |
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