| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Extraordinary skin regeneration of euglena grailis-derived extracellular microvesicles fabricated by cell extrusion |
| 초록 | Extracellular vesicles (EVs) arecell-derived lipid-bound vesicles which can be secreted from almost all typesof cells. Since EVs contain biomolecules of parent cells, their therapeuticefficacy is of great interest in biomedical treatments. However, the isolationof EVs from the cells is time-consuming process with low yields. Theseshortcomings have been tried to be overcome by employing the cell extrusionmethod, in which the cells are extruded through membrane pore. In this study,we introduce euglena gracilis-derived microvesicle (EMVEG)system which was established with aid of the modified-cell extrusion method.Taking advantage of abundant biomolecules encapsulated in the EMVEG,we demonstrate that the EMVEG has practical dermatologicalapplicability for skin regeneration via in vitro scratch assay and western blotanalysis in human keratinocytes. We expect that these EMVEG enableto contribute to biological application in the field of skin therapy andcosmetics. |
| 저자 | 고유리, 백휘라, 김진웅 |
| 소속 | 성균관대 |
| 키워드 | extracellular vesicle; euglena grailis; β-glucan; skin regeneration |
