| 초록 |
3D scaffolds which allow sustained release of bioactive molecules have been considered as an essential component for enhanced bone regeneration. In recent years, combination of various bioactive molecules has been widely investigated to reconstruct more delicate bone. It is well-known that if the certain bioactive molecules with appropriate dose and periods are applied to bone defect, the physiological processes in bone regeneration may be accelerated. However, many studies were not concerned stimulation periods of bioactive molecules during bone formation because of absence of proper release system. In this study, we selected three bioactive molecules (PDGF, VEGF and, BMP-2) which widely used for bone healing and developed porous beads which can regulate release pattern (initial, continuous and, delayed release) of the bioactive molecules. The release profiles of growth factors, and cell behaviors/bone regeneration by different release pattern of the growth factors were investigated. |
