| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | pH-responsive sp2-rich nanodots to inducing photodynamic immune response for cancer treatment |
| 초록 | The low pH of the cancer microenvironmentis targeted for cancer therapy. Herein, we fabricated sp2-rich nanodotsin structure. Nanodots have imidazole group that appear different physicochemicalproperties depending on pH condition. A photosensitizer was encapsulated innanodots internal structure and was released specifically into cancer microenvironment,thereby inducing photodynamic immune response. In tumor-bearing mouse, nanodotstreated with laser-irradiation group showed a significant tumor therapeuticeffect. Moreover, these group of mouse had higher numbers of mature dendriticcells, natural killer cells and CD8 T cells in tumor tissue than compared tothe other experimental groups. Additionally, it was confirmed that distal tumor’sgrowth was effectively hindered by administration of nanodots and laserirradiation. Therefore, pH-responsive nanodots were accumulated to tumor region,and the nanodots facilitated anti-cancer immunotherapy by photodynamic immuneresponse. |
| 저자 | 정하윤, 김다혜, 서정덕, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | Nanodot; cancer immunotherapy |
