| 초록 |
The purpose of the present study was to investigate the pharmacokinetics of DIOS-1, a potential antidote of dioxins, in rats. We also investigated the administration routes such as oral, intramuscular and subcutaneous route. HPLC analysis method usig UV detector was developed. the plasma concentration of DIOS-1 was disappeared after its i.v. administration at a dose of 10 mg/kg. The plasma peak concentration of DIOS-1 after its i.m. ofr s.c. administration at the dose 10mg/kg was 10 ug/ml (tmax=10 min). Thus, s.c. route was considered to be useful compared with i.m. route for the DIOS-1 dministration. On the other hand, the plasm concentration of DIOS-1 was not detected after its oral administration at the dose of 100 mg/kg. On the basis of the simulation results, the accumulation in the body was not demonstrated with DIOS-1 s.c administration at the dose of 10 mg/kg for the dosing interval of 24 hr. In conclusion, s.c. route was considered to be useful for the DIOS-1 administration. |
