| 초록 |
We report the preparation of functional and biocompatible poly(2-oxazoline) (POx)-based nanoparticles of different morphologies and discuss their bio-nano interactions. POx are a highly functional polymer class, which provides access to tailor-made polymers with tuneable physicochemical properties. The water-soluble variants are highly biocompatible, non-immunogenic and show a stealth behavior. Thus, they are highly interesting as shell materials for diverse nanoparticles used in a biological context. In this presentation we will highlight our recent efforts in fabricating spherical and rod-shaped POx nanoparticles through, e.g. emulsion processes, surface coatings of inorganic nanoparticles and crystallization-driven self-assembly (CDSA). The potential to modulate the interaction of these nanoparticles with biological entities through variation of size, shape and polymer/surface modifications will be discussed. |
