| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
THE PERMEATION RATE AS DIFFERENCE OF MICRONEEDLE SHAPE |
| 초록 |
Transdermal delivery is severely limited by the inability of the large majority of drug to cross skin at therapeutic rates due to the great barrier imposed by skin’s outer stratum corneum layer. So, it was the main problem that drug was cross the skin at Transdermal Durg Delivery System (TDDS). In this study, we used The three type of microneedles; roll type, triangle type, crown type. we used FITC labeled insulin as the model drug. It was confirmed that each of microneedle system showed the same tendency regardness the type of microneedle and drug. The triangle type enhanced skin permeation rate related with crown type. Also, crown type enhanced skin permeation rate compared with roll type. It was confirmed that height and number of needle in microneedle system affected drug delivery. Especially, we confirmed that height of needle more influenced skin permeation rate than number of needle. |
| 저자 |
박종학1, 안식일1, 모종현1, 김윤태1, 김명진1, 이종문1, 이해방2, 강길선1
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| 소속 |
1전북대, 2한국화학(연) |
| 키워드 |
TDDS; microneedles; FITC; insulin
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| E-Mail |
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