| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
고분자합성 |
| 제목 |
Study on Dispersion of Drug in biodegradable Matrixes by Time-of-flight Secondary Ion Mass Spectrometry |
| 초록 |
This study investigated the surface structure of drug/polyl-(lactide) (PLLA) mixture films by time-of-flight secondary ion mass spectrometry (TOF-SIMS). The design of the systems was based on the physical mixing and chemical bonding, drug/PLLA and drug end-capped PLLA, respectively. The drug/PLLA mixture showed the phase-separated structure and surface-segregated morphology from drug-fragmental image and its depth profile measurements, respectively. However, the drug end-capped PLLA film showed homogeneous distribution of drugs both in surface and in depth. These results indicate that the drug end-capped PLLA is an useful model for a constant drug-release system. Also release rate would be controlled by the change of a degree of complexation of drug end-capped PLLA/drug end-capped PDLA blends or the change of concentration of drugs in the drug end-capped PLLA. |
| 저자 |
임동혁, 비샬가반데, 이승재, 이원기, 진영읍
|
| 소속 |
부경대 |
| 키워드 |
PLLA; Ion Mass Spectrometry; Durg delivery
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| E-Mail |
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