| 초록 |
Dopamine (DA) molecules are commonly associated with serious diseases, such as Alzheimer’s and Parkinson’s diseases. To improve safety, various analytical devices have been developed to detect dopamine. Herein, we demonstrate the fabrication of field-effect transistor (FET) type dopamine sensor, based on human DA receptor nanovesicles immobilized on carboxylated poly(3,4-ethylenedioxythiophene) (CPEDOT) nanotubes. Liquid-ion gated FET system showed high sensitivity and excellent selectivity toward DA in liquid state. The minimum detectable level (MDL) was as low as 10 pM in real-time, which is 10 times more sensitive than previously reported DA sensors. Moreover, the DA biosensor had a rapid response time (＜ 1 s) and showed excellent selectivity in human serum. |
