| 학회 | 한국공업화학회 |
| 학술대회 | 2015년 봄 (04/29 ~ 05/01, BEXCO (부산)) |
| 권호 | 19권 1호 |
| 발표분야 | (콜로이드계면화학) 나노소재 기술에 있어서 콜로이드 공학의 응용 (중앙대 임경희 교수 정년 퇴임 기념) |
| 제목 | Multilayer Nano-Films for Biomedical Applications |
| 초록 | Recent developments in biomedical engineering, novel cell culture techniques, and newly discovered chemicals as a replacement of the growth factors have opened new area toward the engineered technique of biomedical applications, for use in both research and clinical applications. Ideal bio-platform must be biocompatible that is to say, they should show both proper surface stability for the promotion of cell attachment and functions with drug delivery. However, plenty of challenges are still in progress, as the reason for the high compatibility of polymer film in cell culture environment and precisely controlled functional release of their drugs.. Layer-by-layer (LbL) self-assembly technic has been developed and used to prepared biocompatible multilayer films and polyelectrolyte capsules for drug delivery. Certain drug molecules, such as active proteins, cytokine, growth factors, enzymes, nucleic acids, and DNA, have been immobilized into nano-sized multilayer films. The advantages of LbL multilayer films as drug delivery systems include the variation of candidate materials, also drug molecules itself can use as either functional drugs or components of the film, and easy to combine to additional functions due to their evenly distributed structure. Furthermore sustained drug release is possible through controlling the film physical & chemical properties, in addition multilayer films have the potential to protect drug molecules from losing their biological functions, and the film preparation process is simple and can be automated. The drug release behavior of polyelectrolyte multilayer films depends on the permeability, the disassembly or erosion of the multilayer structure, and other experimental variables. In this presentation, we prepared the cell friendly platform by take full advantages of LbL assembly with evenly distributed drug loading by nano-sized layer assembly. The platforms are prepared by various materials including not only synthetic-, natural-polymers but also functional materials such as growth factors, cytokines which are resulting different film degradation profiles. These results lay a cornerstone for future studies to achieve the multi-functional nanofilms including programmed loading/release of drugs for therapeutic purposes. |
| 저자 | 홍진기 |
| 소속 | 중앙대 |
| 키워드 | Layer-by-layer (LbL) self-assembly; biomaterials; drug delivery |
