| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 포스터-생물공학 |
| 제목 | Bioinspired Surface-Engineering of Stem Cell Spheroids with Dexamethasone-Eluting Depots Promotes Bone Regeneration in Murine Calvarial Defect Model |
| 초록 | Three-dimensional cell culture and bioactive molecule co-delivery with cells have been proposed to enhance cell potency. Here, we surface-engineered mesenchymal stem cell (MSC) spheroids with cell-attachable polydopamine-coated microspheres that release dexamethasone to modulate the fate of MSCs on osteogenesis. Macroporous fibrin scaffold was used to deliver these spheroids. The conjugation was rapid and cell-friendly. DEXA depots significantly enhanced osteogenic differentiation of spheroids. The conjugated particles were stably anchored on MSCs during cell migration. Importantly, DEXA depots facilitated the bone regeneration after implanting the conjugated spheroids into a calvarial defect of C57BL/6 mice. Surface-engineered MSC spheroids with drug depots created a potential for achieving better performance of MSCs. |
| 저자 | NGUYEN TIEN TIEP1, 정지헌2, 육심명1 |
| 소속 | 1계명대, 2성균관대 |
| 키워드 | MSC; tissue engineering; bone regeneration; polydopamine |
