| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
[콜로이드·계면화학] 피부 바이오 혁신연구동향 |
| 제목 |
A nanoparticle-embedded functional platform that controls stem cell differentiation |
| 초록 |
In this study, we report a new platform thatenables neuronal cell generation from stem cells using single metal–organic framework nanoparticle (MOF)-embedded nanohole arrays(SMENA). By optimizing several parameters of nanopatterns, eachnanohole can trap single MOFs that are designed for long-term storage andrelease of retinoic acid (RA). The SMENA prevented physicalinteraction with cells and nanoparticles, which contributed to stability of the MOF structure. Owing to the long-term supply of RA, the neural stem cells showed exhibited mRNA expressions of several neurogenesis-related markers. The developedSMENA platform can be applied to other stem cell sources and differentiationlineages and is therefore useful for various stem cell-based regenerativetherapies. Acknowledgments: This research was supported by the National ResearchFoundation of Korea (NRF) grant funded by the Korea government (MSIT) (GrantNos. NRF-2019M3A9H2031820 and NRF-2019R1A4A1028700). |
| 저자 |
조연우1, 지서현2, 최경민2, 김태형1
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| 소속 |
1중앙대, 2숙명여자대 |
| 키워드 |
Nanohole patterns; Nanoparticles; Drug release; Stem cells; Differentiation
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| E-Mail |
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