| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Nanostructured Polymer Thin Films as A Tool to Control Biointerfaces |
| 초록 | One of the critical issues in the use of biomaterials is “non-specific” adhesion of biomolecules onto the biomaterials.1 To prevent this problem, the surface of the implantable materials should be treated to be “bio-inert, meaning of that is not-reactive for any biological interaction. Previous studies in creating bio-inert coating have been focused on only a few materials, yet the practical methodology to create conformal coating over large-area has not been achieved. Layer-by-layer deposition (LbL) is a versatile technique whereby ultrathin films are assembled from the repetitive, sequential adsorption of oppositely charged polyelectrolytes from dilute aqueous solution.2 It allows nano-scale control over the thickness, composition, and molecular structure of the deposited multilayer film. In previous study, polyacrylamide containing hydrogen-bond driven multilyer films were stabilized by simple crosslinking methods3 and revealed an excellent "anti-fouling" effect, which is the ability to blocking biomolecules adhesion.4 Now we extend the study using other H-bonded multilayers inculding biopolymers, such as hyalluronic acid. In our recent study using 292 epithelial cells and white blood cells, several polymeric surfaces were determined as cell-adhesion controllable surfaces including electrostatically assembled multilayers as well as H-bonded multilayer films. Using a cell-attractive polymers or short peptide ligands, we have studied cellular pattering onto bio-inert surfaces to create cell-arrays. References 1. Ratner, B. D., J. Biomed. Mater. Res. 27, 837 (1993) 2. G. Decher, J. D. Hong, Makromol. Chem. Macromol. Symp. 16, 321 (1991); G. Decher, Science, 277, 1232 (1997) 3. S.Y. Yang, M.F. Rubner, J. Am. Chem. Soc., 124, 2100 (2002) 4. S. Y. Yang, J. Mendelshon, M.F. Rubner, Biomacromolecules, 4 (4), 987 (2003) Figure. 293 cells attachment blocked on the polymer thin film patterned glass |
| 저자 | 양성윤, 서주용 |
| 소속 | 충남대 |
| 키워드 | antifouling; polyelectrolyte; multilayer; cell adhesion; layer-by-layer; bio-inert; peptide |
