| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Tumor-Deconstructible Cationic Nano-micellar Platform for Effective Anti-Tumor Activity in Peritoneal Carcinomatosis |
| 초록 |
In this study, we designed paclitaxel (PTX) loaded bio-reducible positive charged micelles comprising disulfide polyethyleneimine (SS-PEI) as hydrophilic part and lithocholic acid, a secondary bile acid as hydrophobic moiety termed as Lithocholic acid – ssPEI micelles (LAPMi). Introduction of bio-reducible disulfide groups on nanoparticle surface imparts low toxicity and faster destabilization of cargo into the cytoplasm of cancer cells .The cellular uptake of LAPMi was higher in CT26 cells aided to its positive charge and bile acid component. Tumoral reduction environment resulted in controlled and sustained release of PTX in CT26 cells. In vitro and In vivo evaluations demonstrated efficient antitumor effects against intraperitoneal at very low dosage and with no systemic toxicity. In conclusion, PTX loaded nano micelles were considered as potential strategy for treating intraperitoneal cancers. |
| 저자 |
Cherukula Kondareddy1, Rajendrakumar Santhosh Kalash1, Saji Uthaman2, 박인규1
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| 소속 |
1Chonnam National Univ. Medical School, 2Chungnam National Univ. |
| 키워드 |
self-assembly; nano-micelles; GSH; anticancer drug delivery; Intraperitoneal chemotherapy
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| E-Mail |
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