| 초록 |
Tumor microenvironment has unique physiological characteristics such as hypoxic conditions, pH variations, and high reducing potential. Herein, we developed dual stimuli-responsive nanoparticles which is highly stable and sequentially activated at the tumor tissue. The nanoparticles were prepared using an amphiphilic polyethyleneimine derivative with the pH-responsive charge-convertible moiety and the reduction-responsive crosslinking system. We observed that the surface charge of nanoparticle was convertible by responding to the mildly acidic environment of the extracellular level, resulting in the enhanced cellular uptake. Moreover, we confirmed that the chemically crosslinked core of nanoparticle was cleaved by the disulfide bond in the presence of glutathione of intracellular level, allowing for the selective drug release after the cellular uptake. Overall, dual stimuli-responsive nanoparticles showed the high tumor targetability and enhanced anti-tumor efficacy of the drug. |
