| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Effect of Natural Extract Coated on Poly(L-lactic acid) Film on Inhibition of Inflammatory Responses In Vivo |
| 초록 |
The natural extract coated on implantable medical device is one of the alternatives to avoid side effects such as inflammation and infection around implant area. Phenolic compounds in sorghum extract are correlated highly with antioxidant activity. An antioxidant activity has an effect of suppressing an initial excessive inflammatory reaction through quenching reactive oxygen species (ROS) released from macrophages. The depression of the inflammation could be evaluated through measuring various cytokines produced by lipopolysaccharide (LPS)-stimulated macrophages. To further demonstrate in vivo inflammatory response surrounding the implants, sorghum extract coated PLA film was implanted in rats for 1, 3 and 7 days. Tissues surrounding implants were evaluated through H&E staining. The sorghum extract coated on PLA Film reduced inflammation response in vitro and in vivo. |
| 저자 |
이가현1, 박가영2, 최진현2, 이성준2, 정상원1, 김현철1, 황준성1, 한상익1, 이세근3
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| 소속 |
1대구경북과학기술원, 2경북대, 3국립식량과학원 |
| 키워드 |
Natural extract; Inflammatory; In vivo
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| E-Mail |
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