| 초록 |
Functional and synthetic surfaces are required to produce some biochip systems with ultra-sensitivity and without non-specific binding, for the detection of an external analyte.However, the uncontrolled, non-specific adsorption and adhesion of biological materials (e.g., proteins and cells) onto functional and synthetic surfaces causes a complex cascade of undesired events and bioincompatibility problems.It has been well known that poly(ethylene glycol) (PEG) could minimize the unwanted, non-specific adhesion of biological entities. PEG-containing compounds can be synthesized to possess dual properties such as non-biofouling property and functionalizability.Biosensor chips performing high sensitivity, selectivity, and reproducibility would be fabricated onto the PEG-based functional and synthetic surfaces. This work demonstrates the construction of the surfaces that present a functionalizable group with a non- biofouling background by using self-assembling property of poly(PEG-r-NHS). |
