| 초록 |
Polyaniline-grafted nanodiamond (PAN-ND) nanoparticles were prepared by polymerizing aniline on the surface of the amine-modified ND for efficient photothermal therapy (PTT). A series of PANs of different aniline concentrations were also prepared to compare the properties and efficiency of the PTT. The polymerization rate of aniline is faster in the presence of ND than in aniline alone. Compared to PAN nanoparticles, PAN-ND has spherical, small size and ultimately higher cell absorption efficiency. The temperature of the PAN-ND aqueous solution was increased to 44.4 ℃ after laser irradiation for 5 minutes. In addition, the ultraviolet absorption intensity of PAN-ND increased at low pH in the near infrared (NIR) region and showed an improved light heat effect at the cancer site. In particular, the survival rate of HeLa cells treated with PAN-ND decreased to 20% or less, suggesting high efficiency of PTT. PAN-ND can be a potential candidate for effective phototherapy. |
