| 학회 |
한국재료학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 광주 김대중컨벤션센터) |
| 권호 |
27권 1호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
Protein-based Architectures by 2D Shape-controllable Building Blocks and Cationic Molecular Switch |
| 초록 |
Tubulins are protein building blocks that are naturally preprogrammed to assemble into cytoskeletal microtubules (MTs). MTs undergo dynamic transitions in structure for important cellular functions (e.g., cell division), which are achieved by 2D conformational changes of tubulins. We used cationic polymers as a molecular switch, which electrostatically interact with tubulins and alter their conformations, and controlled higher-order tubulin assemblies. Synchrotron small-angle X-ray scattering (SAXS) and transmission electron microscopy (TEM) reveal the tubulin-based architectures in nanoscale – especially, tubulin double helix structure. These findings provide insight into the design of 1) protein-based functional materials that keep intrinsic properties of tubulins such as a high binding affinity with MT-associated proteins or anticancer drugs or 2) metallization templates for nanoscale electronic devices. (J. Lee et al., Small, 2020 (cover issue), J. Lee et al., Advanced Materials, 2020 (cover issue)) |
| 저자 |
이준철1, 송채연1, 이지민1, Herbert P. Miller2, 조하새암1, 김보필1, Youli Li2, Stuart C. Feinstein2, Leslie Wilson2, Cyrus R. Safinya2, 김진주1, 금형섭1, 김유미1, 김유진1, 유병준1, 이상엽1, Junichi Tanaka3, 전상용1, 최명철1
|
| 소속 |
1KAIST, 2UCSB, 3Univ. of the Ryukyus |
| 키워드 |
<P>microtubule; tubulin; protein nanotube; self-assembly; SAXS; TEM</P>
|
| E-Mail |
|
