| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
고분자가공/복합재료 |
| 제목 |
Synthesis of Ester Diselenide-Containing Crosslinker for Core Crosslinked PEO-b-PFMA Micelles |
| 초록 |
In this work, we sucsessfully synthesized the ester diselenide-containing crosslinker. A well-defined amphiphilic block copolymer, poly (ethylene oxide)-b-(poly (furfuryl methacrylate) (PEO-b-PFMA) was prepared by single electron transfer living radical polymerization (SET-LRP). The block copolymer formed sub-100 nm micelles in water with PEO as a shell and PFMA as a core. Diels-Alder click type reaction was employed to form core-crosslinked micelles using a diselenide-containing crosslinker. The stability of core-crosslinked micelles under reductive-oxidative condition was also investigated. The diselenide crosslinked micelles displayed good stability against extensive dilution but decomposed under the presence of hydrogen peroxide or glutathione. The redox-responsive core-crosslinked micelles can be a promising for drug delivery applications |
| 저자 |
임권택, Sabrina Aufar Salma, Cuong M.Q.Le, 김동우, Anugrah D. S. B., 홍성수
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| 소속 |
부경대 |
| 키워드 |
Diels-Alder chemistry; Diselenide Bond; SET-LRP; core-crosslinked micelles; redox-responsive
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| E-Mail |
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