| 학회 | 한국공업화학회 |
| 학술대회 | 2013년 봄 (05/01 ~ 05/03, ICC JEJU) |
| 권호 | 17권 1호 |
| 발표분야 | 포스터-생물공학 |
| 제목 | Antitumor activity of vorinostat-incorporated biodegradable nanospheres against HuCC-T1 cholangiocarcinoma cells |
| 초록 | Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA) is a member of a larger class of compounds that inhibit histone deacetylases (HDAC). Histone deacetylase inhibitors (HDI) have a anticancer activities against various kinds of cancers such as lymphoma, myelodysplastic syndromes and lung cancer, etc. A recent study suggested that vorinostat also possesses anticancer activity against recurrent glioblastoma multiforme, resulting in a median overall survival of 5.7 months. In this study, we fabricated vorinostat-incorporated nanoparticles using poly(ethylene glycol)/polylactide (LE) block copolymer for treatment of cholangiocarcinoma. We obtained positive anticancer activities with vorinostat-incorporated nanoparticles against HuCC-T1 human cholangiocarcinoma cells in vitro and in vivo. |
| 저자 | 곽태원, 김도형, 정정욱, 강대환, 정영일 |
| 소속 | 양산 부산대병원 |
| 키워드 | vorinostat; SAHA; vorinostat-incorporated nanoparticle; cholangiocarcinoma |
