| 학회 |
한국공업화학회 |
| 학술대회 |
2015년 가을 (11/04 ~ 11/06, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
19권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Vorinostat-incorporated nanoparticles for local delivery into human cholangiocarcinoma |
| 초록 |
This study was to evaluate the anticancer activity of vorinostat and vorinostat-incorporated nanoparticles (VNPs) against HuCC-T1 human cholangiocarcinomas. VNPs were fabricated using poly(DL-lactide-co-glycolide)/poly(ethylene glycol) copolymer. VNPs have anticancer activity similar to that of vorinostat in vitro. Both vorinostat and VNPs have equal potency in terms of inhibition of histone deacetylase expression, mutant-p53 suppression, increased p21 expression and PARP/cleaved caspase-3 expression. However, VNPs showed improved antitumor activity against HuCC-T1 cancer cell-bearing mice compared to vorinostat, whereas empty nanoparticles had no effect on tumor growth. The improved anticancer activity of VNPs can be explained by molecular imaging study using near-infrared dye-incorporated nanoparticles, that were intensively accumulated in the tumor region rather than normal one. Our results demonstrate that vorinostat and VNPs exert anticancer activity against HuCC-T1 cholangiocarcinoma. Thus, we suggest that VNPs are a promising candidate for anticancer chemotherapy in cholangiocarcinoma. |
| 저자 |
강대환1, 정영일2, 송연희3, 이혜림4, 곽태원3
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| 소속 |
1부산대병원 / 양산 부산대병원, 2부산대병원, 3양산 부산대병원, 4순천대 |
| 키워드 |
Vorinostat; Cholangiocarcinoma; Nanoparticles; Poly(DL-lactide-co-glycolide); block copolymer; Cancer chemotherapy; Drug targeting
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| E-Mail |
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