| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Poly(Amino Acid) based adjuvants containing squalene for enhancing both cell-mediated and humoral immune responses against influenza virus |
| 초록 |
Adjuvants improve vaccine efficacy by accelerating and prolonging immune response and also by lowering the required dose and reducing side-effects. Currently, there is major research effort to develop powerful adjuvants for purified or synthetic recombinant vaccines that are safer but less immunogenic. Particularly, adjuvants that enhance cell-mediated (Th1) immunity are in great demand but very rare. In this study, we have developed a novel squalene-based cationic poly(amino acid) adjuvant (CASq) which elicits both cellular (Th1) and humoral (Th2) immune responses. CASq was demonstrated to promote cellular uptake of viral antigen and stimulate macrophages, leading to active production of IL-12. Further, co-administration of inactivated pdm H1N1 vaccine with CASq significantly increased generation of antigen-specific antibodies and T cell immune responses in mice, and resulted in complete prevention of disease symptoms and protection against lethal infection. |
| 저자 |
임종우1, 김현욱1, 박근선1, 박채원1, 송대섭2, 함승주1
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| 소속 |
1연세대, 2고려대 |
| 키워드 |
백신; 아미노산; 고분자
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| E-Mail |
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