| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Characterization and Improved Dissolution Rate of Aceclofenac Solid Dispersion in PVP |
| 초록 |
We prepared nanoparticles containing insoluble aceclofenac by the method of solid dispersions using spray dryer to improve solubility of aceclofenac. We used PVP-K30 as a water soluble carrier for the solid dispersion and poloxamer as a surfactant. Characterization of aceclofenac solid dispersion was performed by SEM, DSC, XRD and FT-IR. The results of SEM, DSC and XRD demonstrated that aceclofenac is amorphous in solid dispersion. The formation of salt by hydrogen bond between aceclofenac and PVP K-30 was confirmed by FT-IR. The dissolution rate measured in intestinal juice showed the method of solid dispersion improved aceclofenac solubility as compared with a conventional drug(Airtal®). In conclusion, the method of solid dispersion using spray dryer would improve solubility of aceclofenac in oral administration. |
| 저자 |
박현진, 홍동현, 김혜린, 유동혁, 조한수, 송병주, 안우영, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Aceclofenac; Solid dispersion; PVP K-30; Spray-drying
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| E-Mail |
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