| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Self-assembled Flt1 peptide-hyaluronic acid conjugate nanoparticles for the treatment of asthma |
| 초록 |
Dexamethasone (Dexa) loaded Flt1 peptide – hyaluronic acid conjugate (Flt1 – HA) nanoparticles were successfully prepared for the treatment of neutrophilic pulmonary inflammation. In vitro bioimaging showed efficient internalization of Flt1 – HA nanoparticles into lung epithelial cells. Also, ex vivo imaging for the biodistribution in ICR mice revealed long-term retention of Flt1 – HA nanoparticles in deep lung. On the basis of bioimaging results for pulmonary drug delivery applications, we prepared Dexa-loaded Flt1 – HA nanoparticles. TEM and DLS confirmed the formation of nanoparticles, which reduced cytokine levels of lipopolysaccharide (LPS)-stimulated cells more efficiently than free Dexa. Furthermore, according to the bronchoalveolar lavage (BAL) cellularity and histological analysis, Dexa loaded Flt1 – HA nanoparticles showed remarkable therapeutic effects in both eosinophilic and neutrophilic asthma model mice. |
| 저자 |
황병우1, 김혜민2, 박현택2, 태유미2, 공원호2, 성동경2, 김기수2, 김윤근2, 한세광2
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| 소속 |
1포항공과대, 2포항공대 |
| 키워드 |
Hyaluronic acid; Flt1 peptide; Dexamethasone; Nanoparticle; Asthma
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| E-Mail |
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