| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
대학원생 구두발표 |
| 제목 |
In Situ Forming Hyaluronate Hydrogels by Host-Guest Chemistry Encapsulating Mesenchymal Stem Cells for Cancer Therapy |
| 초록 |
Biomimetic supramolecular hydrogels were successfully developed using hyaluronate (HA) conjugated with cucurbit[6]uril (CB[6]) and polyamines (PAs). The strong and selective host-guest interaction between CB[6] and PA made possible supramolecular assembly of CB[6]/PA-HA hydrogels in the presence of cells. Then, the 3D environment of CB[6]/PA-HA hydrogels could be modularly modified by the simple treatment with various multifunctional tags-CB[6]. Engineered mesenchymal stem cells (MSCs) to release interleukin-12 (IL-12), which were encapsulated in the supramolecular injectable CB[6]/DAH-HA hydrogles, showed a significant inhibitory effect on tumor growth. Taken together, CB[6]/DAH-HA hydrogels were thought to be effectively exploited for various drug delivery and tissue engineering applications. |
| 저자 |
염준석, 정현태, 박상훈, 양정아, 황병우, 김기문, 성영철, 한세광
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| 소속 |
POSTECH |
| 키워드 |
Hyaluronate; Cuccurbituril; Hydrogel; Host-guest chemistry; Stem cell; Cancer therapy
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| E-Mail |
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