| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Supramolecular Hyaluronate Hydrogels for Bioengineered Stem Cell Therapy |
| 초록 |
Synthetic hydrogels have been extensively investigated as artificial extracellular matrices (ECMs). Crucial challenges for such hydrogels are sustaining long-term encapsulation and providing appropriate cues for spatio-temporal control of the cells. Here, we report in situ supramolecularly assembled and modularly modified hydrogels for long-term engineered mesenchymal stem cell (eMSC) therapy using cucurbit[6]uril conjugated hyaluronic acid (CB[6]-HA), diaminohexane conjugated HA (DAH-HA), and drug conjugated CB[6] (drug-CB[6]). The eMSCs producing enhanced green fluorescence protein (EGFP) remained alive and emitted the fluorescence within CB[6]/DAH-HA hydrogels in mice for more than 60 days. Furthermore, the long-term expression of mutant interleukin-12 (IL-12M) resulted in effective inhibition of tumor growth with a significantly enhanced survival rate. Taken together, our findings confirm the feasibility as 3D artificial ECMs for cell therapies and tissue engineering applications. |
| 저자 |
황병우, 염준석, 김수진, 남궁홍, 양정아, 한세광
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| 소속 |
포항공과대 |
| 키워드 |
Hyaluronic acid; Host-guest interaction; Supramolecular hydrogel; Stem cell therapy
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| E-Mail |
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