| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 가을 (11/08 ~ 11/10, 부산 벡스코(BEXCO)) |
| 권호 |
21권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
The influence of hair loss and anti-inflammatory effect of natural extract complex (NEC) in hair follicle dermal papillar cells(HFDPCs). |
| 초록 |
Hair loss is caused by hormone testosterone and the occurrence of seborrheic dermatitis due to scalp inflammation. 5α-reductase plays a role of converting testosterone to dihydritestosterone (DHT) which inhibits growing healthy hair, while shrinking hair follicles. In this study, NEC is evaluated that the regulation of 5α-reductase activity and inflammatory effects, compared with finasteride(5α-reductase inhibitor). The effects of NEC on hair loss and cell death were recorded by western blot and by ELISA for inflammatory effect. NEC leaded lower level than finasteride in expression of 5α-reductase in HFDPCs. NEC prevented apoptotic cell death resulting in prolonging the anagen phase through anti-apoptotic effects. Protein level of TNF-alpha, IL-1,4,6 which were increased by PMACI, were inhibited by NEC. Thus, these results imply that NEC can be a candidate for the regulating of hair loss. |
| 저자 |
심혜은1, 홍윤정2, 문지연2, 이은경2, 박지혜2, 강명균3, 권보선2
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| 소속 |
1우리들휴브레인, 2위노바, 3안전성평가(연) |
| 키워드 |
natural extract complex; hair loss; inflammation
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| E-Mail |
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