| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
The development of injectable hydrogel as disc filler to treatment of degenerative disc or disc hernias using Thermomatrix |
| 초록 |
The most widely used chymopapain for chemonucleolysis was withdrawn from the market due to its anaphylactic reactions. To overcome these complications, the development of alternative without side-effects is a recent challenge in the field of bioengineering to treat back pain accompanying disc degeneration. In this study, Thermomatrix(Winnova Co. Ltd, Korea) was developed by hydrophobically modifying glycol chitosan, which has thermosensitive sol-gel transition, to reduce hernia symptoms. Lumbar disc segments were retrieved from sacrificed miniature porcine. After disc degeneration with the injection of chondroitinase ABC to porcine discs, hydrogel mixture accompanied with barium sulfate and ethyl alcohol was injected into the pre-defected site. After 4 week cultivation, discs were characterized with radiographic images and histological analysis |
| 저자 |
홍윤정1, 문지연1, 심혜은2, 김세희2, 권보선3
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| 소속 |
1(주)위노바, 2우리들휴브레인(주), 3(주)위노바 / 우리들휴브레인(주) |
| 키워드 |
Themomatrix; injectable hydrogel; disc filler
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| E-Mail |
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