| 초록 |
Development of a chronic tissue-like peripheral neural interface is challenging due to the lack of a rational material design that mimics the dynamic mechanical nature of the nerves. The soft electronic materials should be soft and stretchable and even molecularly dynamic, such that an autonomous mechanical adaptation is feasible to the nerves. Here, we report a mechanically adaptive electronic epineurium comprising a stretchable self-healing polymer and its conductive composite capable of forming compressive stress-free and strain-insensitive nerve-electronics interfaces owing to a dynamic stress relaxation. The mechanical adaptability of our electronics can significantly reduce the mechanical mismatch at biotic-abiotic interfaces, which minimizes compressive stress without causing immune responses and device failure. We demonstrate a bidirectional neural signal recording and modulation in a rat sciatic nerve model for 14 weeks. In addition, a simple potential scenario for rehabilitation of spinal cord injury patients was performed via a peripheral nerve-to-nerve interfacing. Our new biotic/abiotic neural system can lead to an unprecedented class in electronic medicines for neurological disorders. |
