| 학회 | 한국공업화학회 |
| 학술대회 | 2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 | 24권 1호 |
| 발표분야 | 포스터-생물공학 |
| 제목 | Self-assembled β-glucan micro/nanoparticles for the delivery of therapeutic molecules |
| 초록 | β-Glucan has properties of biocompatibility, biodegradability, high stability, and low toxicity; therefore, it can be used as a drug-delivery system and therapeutic target. We designed porous, hollow β-glucan microparticles (YGlu) with doxorubicin (DOX), an anticancer drug. We confirmed the successful loading of the drugs in YGlu by chitosan and alginate electrostatic attraction (Mat) through scanning electron microscopy, UV−vis spectroscopy, and Fourier transform infrared spectrometry. We also examined the cytotoxicity and efficiency of YGlu/Mat/DOX in MDA-MB-231 cells, HUVEC cells, and human peripheral blood mononuclear cells (PBMCs). In addition, we investigated the effects of YGlu on the secretion of cytokines in PBMCs. These results suggest that the YGlu/Mat/DOX may be utilized as a promising platform for drug delivery. |
| 저자 | 이경우, 장재희, 최종훈 |
| 소속 | 중앙대 |
| 키워드 | β-glucan; Self-assembly; micro/nanoparticles; drug-delivery |
