| 초록 |
There are urgent global issues associated with infection of biofilms which exhibit resistance to external stimulation. Despite the problem, the effective treatments is still lack. Until now, metal nanoparticles(NP) have been known as antimicrobial and antibiofilm agents. Herein, Ag and Cu bimetallic NP on a graphene oxide(GO) nanosheets that functionalized with oxygen containing group and optimal substrate to fabricate nanocomposites were sythesized using a chemical reduction method. Ag/Cu/GO were characterized by transmission electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray diffraction spectroscopy. The cytotoxicity of the Ag/Cu/Go was also confirmed using fibroblasts from skin, and its antibacterial activity was evaluated. As a result, the fabricated Ag/Cu/Go had a effective killing activity against the three bacterial species at concentrations that have no cytotoxicity. Also, the inhibitory effect of the biofilm formation was confirmed using microfluidic systems. |
