| 학회 |
한국화학공학회 |
| 학술대회 |
2016년 가을 (10/19 ~ 10/21, 대전컨벤션센터) |
| 권호 |
22권 2호, p.1849 |
| 발표분야 |
생물화공 |
| 제목 |
Dendrimer porphyrin and Gold Nanoshells-decorated Nanoparticle Systems for Dual Phototherapy of Cancer |
| 초록 |
Photodynamic therapy (PDT) is excellent method for the treatment of cancer. It involves the systemic administration of photosensitizers (PS) such as porphyrin and phthalocyanine, so PS transfers photon energy to generate cytotoxic reactive oxygen species (ROS) to kill cancer. In the case of photothermal therapy (PTT), it involves the conversion of absorbed photon energy into the heat by using gold nanomaterials. In this work, 3rd generation dendrimer porphyrin was deposited onto gold nanoshell coated silica nanoparticles via Layer-by-Layer method. The successful fabrication of this system was monitored by UV–Vis spectroscopy, high resolution TEM, and electrophoretic light scattering spectrophotometer. Also, photodynamic and photothemal effect of nanoparticles under light exposure was confirmed by conducting ROS generation and temperature increase test. Furthermore, synergistic combined phototherapy including PDT and PTT was achieved through cell viability using the MTT assay. |
| 저자 |
정의석, 한상원, 윤병주, 정윤아, 김은경, 장우동, 고원건
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| 소속 |
연세대 |
| 키워드 |
의약생물공학; 바이오칩/나노바이오공학
|
| E-Mail |
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| 원문파일 |
초록 보기 |
