| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Regeneration Effect of Visible Light-Curing Furfuryl Alginate Compound by Release of Epidermal Growth Factor for Wound Healing Application |
| 초록 |
Alginate was modified with furfurylamine, and the furfuryl alginate (F-alginate) was mixed with Rose Bengal for visible light reactivity. The introduction of furfuryl group was confirmed by 1H-NMR and UV/VIS spectroscopy. Visible light-induced crosslinking was evaluated by micropatterning and weight measurement. Swelling ratio was also determined. To verify its applicability in wound healing applications, EGF was included in the system of F-alginate and Rose Bengal. After the confirmation of no cytotoxicity of F-alginate and murine EGF release from the system, cell proliferation, antibacterial activity, and animal test were performed on the system. In conclusion, it was demonstrated that the system was useful for wound healing. Acknowledgement : This work (Grants No. C0150782) was supported by Business for Cooperative R&D between Industry, Academy, and Research Institute funded Korea Small and Medium Business Administration in 2013. |
| 저자 |
허윤, 김은혜, 정진홍, 한가득, 장연도, 손태일
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| 소속 |
중앙대 |
| 키워드 |
alginate; wound healing; furfuryl; epidermal growth factor (EGF); drug delivery system
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| E-Mail |
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