| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Gd conjugated organic nanoparticles with Enhanced r1 relaxivity and photothermal therapy |
| 초록 |
Developing well-designed T1 imaging agents has been highlighted nowadays because of several disadvantages of T2 contrast agent such as low contrast and distortion of neighboring tissues. In addition to the efficient T1 imaging, localized therapy has been persued for the cancer therapy. Therefore we syntheszied Gd (III) chelated polymer nanoparticles (GPNPs) which could be applied in highly T1 enhanced imaging and photothermal therapy. Moreover, therapeutic antibody was conjugated on the GPNPs for the specific diagnosis and therapy of cancer. Fabricated GPNPs represented significantly high relaxivity (r1) as well as photothermal ability. The physicochemical properties and biocompatibilities of GPNPs were fully analyzed and GPNPs exhibited excellent tumor targeting ability, diagnosis efficacy and photothermal ability. Consequently, GPNPs exhibited strong potential for efficient diagnosis of cancer in MR imaging and phothermal ablation of epithelial cancer cells. |
| 저자 |
이택수1, 방도연1, 이재민1, 최지혜1, 서진석2, 허용민1, 함승주1
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| 소속 |
1연세대, 2영상의학과 |
| 키워드 |
Magnetic resonance imaging; gadolinium; theragnosis
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| E-Mail |
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