| 초록 |
In this study, arginine was conjugated with Pal-GHK to get Pal-GHK‐R4 and wrinkle improvement clinical trials of cosmetics containing Pal-GHK‐R4 were conducted. As a result of total 21 subjects used the test products 4 weeks use on the face area; 1) measurement results of crow’s feet, analysis value of crow’s feet statistically significantly decreased after 2 and 4 weeks; 2) measurement results of skin moisturization, measured value of skin moisture content statistically significantly increased after 2 and 4 weeks; measurement results of TEWL after 2 and 4 weeks use, measured value of TEWL statistically significantly decreased after 2 and 4 weeks use. 3) there was no skin adverse event reported after using the products during the study period. Therefore, the test products containing both wrinkle improving and skin penetrating peptides, Pal-GHK‐R4 are considered to have beneficial effects on improvement of skin wrinkle, moisturization, TEWL after 2 and 4 weeks use of test product. |
