| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
NGF-immobilized Porous Beads as a Bioactive Urethral Bulking Agentfor the Treatment of Urinary incontinence |
| 초록 |
Stress urinary incontinence, one type of the urinary incontinence, may be caused by urethral hypermobility and/or intrinsic sphincter deficiency. Various injectable bulking agents have been used in the treatment of stress urinary incontinence. However, injection volume decrement with time caused by particle migration and resorption in the body have been main problems for them. In this study, we prepared growth factor (NGF)-immobilized porous polycaprolactone (PCL)/Pluronic F127 beads as an injectable and bioactive bulking agent which can provide bulking effect and lead to regeneration of the defect nerves and thus stimulate smooth muscle around urethra for the effective treatment of urinary incontinence. Their morphology, growth factor release behaviors and the animal study (using an urinary incontinence rat model) to investigate the effectiveness of the porous beads as a bioactive bulking agent (in vivo) were conducted. |
| 저자 |
김상준1, 김인걸2, 오세행1, 이지열2, 이진호1
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| 소속 |
1한남대, 2가톨릭대 |
| 키워드 |
urinary incontinence; porous bead; NGF; bulking agent
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| E-Mail |
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