| 학회 |
한국화학공학회 |
| 학술대회 |
2017년 가을 (10/25 ~ 10/27, 대전컨벤션센터) |
| 권호 |
23권 2호, p.2516 |
| 발표분야 |
WISET 여대학(원)생 공학연구팀제 지원사업 결과 발표대회(여성위원회) |
| 제목 |
화장품 유효성/안전성 평가용 인공 피부 플랫폼 개발 연구 |
| 초록 |
The skin on a chip is one of the studies that has attracted attention because it can be used to screen the toxicity and efficacy of certain materials including cosmetics, skin detergents and drugs by various limitations of animal experiments such as the ethical and regulatory issues and the considerable difference between animals and human. For this reason, we investigated the in vitro three dimensional vascularized skin on a chip to mimic the structures and functional responses of the human skin using collagen/fibrin hydrogel(CFH) for dermis and poly(l-lactide-co-caprolactone)(PLCL) nanofibrous electrospun membrane(NEM) for epidermis. To mimic vessels, we created channels in the CFH and coated with human umbilical vein endothelial cells(HUVECs). Consequently, we could find that channels coated with HUVECs formed a vessels-like structure, and microvascular networks were formed in CFH like the dermis. Moreover, it was confirmed that PLCL-NEM formed the epidermis like structure. Our results suggest that the vascularized skin-on-a-chip model can potentially be used for testing the toxicity of cosmetics or drugs. |
| 저자 |
김태희1, 정영미2, 이정은3, 김민정4, 이주희5, 정은채4
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| 소속 |
1KU-KIST, 2KIST, 3중앙대, 4동덕여자대, 5건국대 |
| 키워드 |
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| E-Mail |
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| VOD |
VOD 보기 |
| 원문파일 |
초록 보기 |
