| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Potassium homeostasis-disturbing polypeptide induced ER stress-mediated apoptosis. |
| 초록 |
Perturbation of potassium homeostasis can affect various cell functions and lead to the onset of programmed cell death. Although ionophores have been intensive used as an ion homeostasis disturber, the mechanisms of cell death are unclear and the bioapplicability are limited. In this study, helical polypeptide-based potassium ionophores were developed to induce endoplasmic reticulum stress-mediated apoptosis. The polypeptide-based potassium ionophores disturbed ion homeostasis and then induced prolonged endoplasmic reticulum stress in the cells. The endoplasmic reticulum stress resulted in oxidative environments that accelerated the activation of mitochondria-dependent apoptosis. This study provides the first evidence showing that helical polypeptide-based potassium ionophores trigger endoplasmic reticulum stress-mediated apoptosis by perturbation of potassium homeostasis. |
| 저자 |
이대용, 김유천, 김문식
|
| 소속 |
한국과학기술원 |
| 키워드 |
ER stress; apoptosis; perturbed potassium homeostasis
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| E-Mail |
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