| 초록 |
Obesity has emerged as one of serious global health concerns and its associated metabolic disease, type 2 diabetes, threat human health. In order to treat obesity, brown adipose tissues (BAT) have been reported as a primary target due to its capability for promoting adaptive thermogenesis by dissipating energy. However, previous studies reported that some drugs for activating BAT have serious side effects causing safety concerns for clinical uses. We hypothesized that stem cell-derived exosomes could be effective therapeutic tools for activating brown fat and inducing adipose tissue browning. Stem cell-derived exosomes were intra-peritoneally injected into high fat-fed mouse models. Diet-induced obesity was attenuated in the mouse model by inducing BAT activation and adipose tissue browning. Our results represent that stem cell-derived exosomes provide a promising platform for preventing diet-induced obesity and its associated metabolic disease. |
