| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Synthesis of N-acetylated glycol chitosans and their thermosensitive sol-gel transition properties |
| 초록 |
In this study, new glycol chitosan-based thermo-sensitive polymers were synthesized and their thermo-sensitive sol-gel transition properties were evaluated. Glycol chitin structures were successfully introduced by N-acetylation reaction of glycol chitosan. The aqueous solutions of glycol chitins demonstrated unique thermo-sensitive sol-gel transition behaviors around 37℃. Their sol-gel transition properties were observed at a relatively lower concentration range (3~16wt%) compared to those of typical synthetic polymer based systems, which were efficiently modulated by varying the molecular weight, the DA, and the concentration. Based on their thermo-sensitivity, low cyto-toxicity, and high gel stability, the glycol chitin polymers have great potential for various biomedical applications, such as drug delivery, tissue engineering, and 3D cell culture. |
| 저자 |
조익성1, 유호선2, 조명옥1, 이정정3, 김남홍1, 장미경1, 강선웅4, 허강무5
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| 소속 |
1충남대, 2카이스트, 3안전성평가(연), 4천진과학기술대, 5순천대 |
| 키워드 |
glycol chitosan; sol-gel transition; N-acetylation; thermo-sensitive hydrogel
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| E-Mail |
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