화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2007년 가을 (10/11 ~ 10/12, 일산킨텍스)
권호 32권 2호
발표분야 신진연구자 특별 심포지움
제목 Rational design of multi-functional non-viral gene delivery to specific tissues
초록 The delivery of therapeutic genes to neurons has the potential to treat neurological disease and spinal cord injury. Nonviral vectors are an attractive alternative in that they offer improved safety profiles compared to viruses and can be targeted to specific neuronal subpopulations. However, most nonviral vectors suffer from significantly lower transfection efficiencies than neurotropic viruses. The development of minimally-invasive, non-viral gene delivery vehicles for the central nervous system (CNS) is an important technology goal in the advancement of molecular therapies for neurological diseases. One approach is to deliver materials peripherally that are recognized and retrogradely transported by motor neurons toward the CNS. This approach, especially tissue-specific targeting technique, can also be applied for gene therapy of cardiovascular disorders.
저자 박인규1, Jurate Lasiene2, Shinn-Huey Chou3, Philip J. Horner4, 정명호5, 안영근2, Suzie H. Pun3
소속 1전남대, 2Seattle, 3WA 98195, 4USA, 5Univ. of Washington
키워드 Neuronal gene therapy; tetanus toxin; retrograde transport
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