| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_고분자 |
| 제목 |
Near-Infrared Light-Responsive Alginate Hydrogels Based on Diselenide-Containing Cross-Linkage for on Demand Degradation and Drug Release |
| 초록 |
A biodegradable, near-infrared (NIR) - responsive hydrogel is one of the most promising strategies as a remotely triggered drug carrier. A novel NIR-responsive hydrogels based on alginate structures were prepared for controllable drug release. The hydrogels were formed rapidly by reacting norbornene-functionalized alginates and tetrazine cross-linkers containing diselenide bonds via inverse electron demand Diels-Alder click chemistry. NIR sensitive indocyanine green (ICG) and a drug, doxorubicin (DOX) were incorporated in the hydrogel matrix during gelation. The hydrogels showed a suppressed release profile under physiological conditions, while NIR light triggered a rapid release of DOX. Under NIR-light irradiation, ICG generated reactive oxygen species which could decompose diselenide bonds in the hydrogel matrix, inducing the gel-sol transition and release of entrapped DOX. |
| 저자 |
박한솔, Daru Seto Bagus Anugrah, 안병현, 임권택
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| 소속 |
부경대 |
| 키워드 |
NIR-responsive; Alginate; Hydrogel; Diselenide; Inverse electron demand diels-alder.
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| E-Mail |
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