| 초록 |
Although frequent administration of corticosteroid, such as dexamethasone(Dex), is associated with severe side effects, Dex is the most essential treatment for asthma. One promising strategy to enhance the therapeutic efficacy without any side effect is loading Dex in biocompatible drug carrier. Based on the fact that hydrogen peroxide concentration in the lung of asthmatic sufferers is higher than normal patients, we prepared H2O2-responsive nanoparticles Dex-BM (Dex-loaded boronated maltodextrin) as a drug carrier by encapsulating Dex to BM polymer. Dex-BM nanoparticles were designed to undergo H2O2-triggered hydrolytic degradation to release dex and hydroxy benzyl alcohol which exert antioxidant and anti-inflammatory activities. Dex-BM nanoparticles significantly inhibited expression of pro-inflammatory IL-13 and TNF-α. We therefore anticipate Dex-BM nanoparticles hold tremendous potential as therapeutic systems for the treatment of airway inflammatory diseases such as asthma. |
